50-24-8 Prednisolon

Brief Description
CAS No.: 50-24-8 Other Names: Prednisolon MF: C21H28O5
EINECS No.: 200-021-7 Place of Origin: China (Mainland) Type: Pharmaceutical Intermediates, Syntheses M...
Purity: 99%min Brand Name: sinoright Model Number: BP
Application: medicine Appearance: white powder color: white
Delivery Terms & Packaging
Packaging Detail:1kg/tin 10tin/carton
Delivery Detail:PPT
Specifications
50-24-8 Prednisolon

50-24-8 Prednisolon
Other Names: prednisolone
MF: C21H28O5
EINECS No.: 200-021-7

50-24-8 Prednisolon
Other Names: prednisolone 
MF: C21H28O5 
EINECS No.: 200-021-7  
 

Uses:Prednisolone is a corticosteroid drug with predominant glucocorticoid and low mineralocorticoid activity, making it useful for the treatment of a wide range of inflammatory and auto-immune conditionssuch as asthma.uveitis, pyoderma gangrenosum, rheumatoid arthritis, ulcerative colitis, temporal arteritis and Crohn's disease, Bell's palsy, multiple sclerosis, cluster headaches, vasculitis, acute lymphoblastic leukemia and autoimmune hepatitis,systemic lupus erythematosus, and dermatomyositis. It is also used for treatment of sarcoidosis, though the mechanism is unknown.

Prednisolone acetate ophthalmic suspension (eye drops) is an adrenocortical steroid product, prepared as a sterile ophthalmic suspension and used to reduce swelling, redness, itching, and allergic reactions affecting the eye.

Prednisolone can also be used as an immunosuppressive drug for organ transplants and in cases of adrenal insufficiency (Addison's).

Corticosteroids inhibit the inflammatory response to a variety of inciting agents and, it is presumed, delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation with inflammation.

Mechanism of action

Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. AlphaGR and BetaGR are found in virtually all tissues with variable numbers between 3000 and 10000 per cell, depending on the tissue involved. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They both induce synthesis of some genes and, therefore, some proteins, and inhibit synthesis of others.

Not all metabolic actions on genes are known. Most mediator proteins are enzymes, e.g., cAMP-dependent kinase

Anti-inflammatory and immunosuppressive actions:

  • Inhibition of gene transcription for COX-2, cytokines, cell adhesion molecules, and inducible NO synthetase
  • Blockage of Vit D3-mediated induction of osteocalcin gene in osteoblasts
  • Modification of collegenase gene transcription
  • Increase synthesis annexin-1, important in negative feedback on hypothalamus and anterior pituitary gland
  • Anti-inflammatory action, it is presumed.

Regulation of gene suppression leads to systemic suppression of inflammation and immune response. This is of clinical usefulness but ultimately leads to gluconeogenesis protolysis and lypolysis. Gene transcription returns to normal after cessation, but sudden stoppage can cause Addison's disease. Osteoporosis is permanent.