Amoxicillin Trihydrate

Brief Description
CAS No.: 61336-70-7 Other Names: alpha-Amino-p-hydroxybenzylpenicil... MF: C16H19N3O5S,3H2O
EINECS No.: 248-003-8 Place of Origin: China (Mainland) Type: Antibiotic and Antimicrobial Agents
Grade Standard: Medicine Grade Usage: Animal Pharmaceuticals Brand Name: CR
Model Number: USP/EP/BP/CHP/JP Purity: 99% Color: White to Whitish
PH: 3.5-6.0 Water: 11.5%-14.5% 
Delivery Terms & Packaging
Packaging Detail:25kg/drum
Delivery Detail:within 20 days after the order being confirmed
Specifications
Amoxicillin Trihydrate

Amoxicillin Trihydrate
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Characteristics and applications

AMPICILLIN is a semisynthetic antibiotic, a member of the penicillin family of antibiotics. To extend the usefulness of the penicillins to the treatment of infections caused by gram-negative rods, the broad-spectrum penicillins (ampicillin, amoxicillin, carbenicillin, and ticarcillin) were developed.  It is created by attaching acid radicals to the central structure of 6-aminopenicillanic acid. Chemically, it is D-(-)-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7 -oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid trihydrate.  Similar in action to penicillin G--the most widely used natural penicillin--ampicillin (or alpha-aminobenzylpenicillin) is more stable in stomach acids and therefore may be given orally; it is also more active against certain strains of bacteria. It is used regularly to treat common urinary-tract infections, some respiratory infections, and bacterial meningitis in children, although many strains of Hemophilus influenzae (the most common cause of bacterial meningitis) are now resistant to ampicillin, and it commonly is used along with other drugs. The potential side effects of ampicillin are similar to those of other penicillins--i.e., chiefly allergic reactions ranging from skin rashes and hives to life-threatening anaphylactic shock (very rare). People who are allergic to other drugs in this family are also likely to react to ampicillin. The incidence of skin rashes is higher with ampicillin than with other penicillins, a factor that suggests a possible toxic reaction, as well as a truly allergic response. AMOXICILLIN is a semisynthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against many gram-positive and gram-negative microorganisms. Chemically it is (2S,5R,6R)-6-[(R)-(-)-2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo- 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate. Amoxicillin is useful in treating urinary tract infections caused by gram-negative rods as well as in treating typhoid and enteric fevers.

Storage / transportion

It should be stored in a dry and ventilated warehouse and avoid sundry odors pollution. Sunlight and rain should be prevented during transportation.

Usage

Amoxicillin, formerly amoxycillin (BAN), tormoxin (in India), amoxycillin (cilamox) in Australia, abbreviated amox, is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other β-lactam antibiotics. It is also a treatment for cystic acne.

Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, which are resistant to a broad spectrum of β-lactam antibiotics, such as penicillin. For this reason, it is often combined with clavulanic acid, a β-lactamase inhibitor, and marketed under one name. This increases effectiveness by reducing its susceptibility to β-lactamase resistance.

Package

25kg/drum

Description

White or white crystalline powder, slightly soluble in water, insoluble in the product in chloroform, ethanol, ethyl ether, or non-volatile oil ;  dissolve in dilute acid solution or  dilute alkali solution.

Specification

Amoxicillin is a moderate-spectrum antibiotic active against a wide range of
Gram-positive, and a limited range of Gram-negative organisms. It is usually the drug
of choice within the class because it is better absorbed, following oral administration,
than other beta-lactam antibiotics.

Standard: USP/EP/BP/CHP/JP

ITEM

STANDARD

DESCRIPTION

A WHITE CRYSTALLINE POWDER

IDENTIFICATION

THE IR SPECTRUM OBTAINED WITH THE SUBSTANCE TO BE EXAMINED SHOULD CORRESPOND WITH THAT OBTAINED WITH USP AMOXICILLIN RS

CRYSTALLINITY

SHOW BIREFRINGENCE AND EXTINCTION POSITIONS

PH

3.5-6.0

WATER

11.5%-14.5%

N,N-DIMETHYLANILINE

≤20PPM

ASSAY

900-1050μg/mg C16H19N3O5S

(CALCULATED ON THE

ANHYDROUS BASIS)