RIFAMPICIN

Brief Description
CAS No.: 13292-46-1 Other Names: RIFAMPICIN MF: C43H58N4O12
EINECS No.: 236-312-0 Place of Origin: Shaanxi China (Mainland) Type: Antibiotic and Antimicrobial Agents
Grade Standard: Medicine Grade Brand Name: sciphar Model Number: sp113
Purity: 98% product name: RIFAMPICIN CAS No.: 13292-46-1
Molecular weight: 822.95  
Delivery Terms & Packaging
Packaging Detail:25kg/drum
Delivery Detail:3days
Specifications
RIFAMPICIN

Rifampicin or rifampin (USAN) is a bacteriostatic antibiotic drug of the rifamycin group.

RIFAMPICIN

CAS No. 13292-46-1

Molecular formulaC43H58N4O12

Molecular weight822.95

Formulation: bright red or the dark crystal powder

Rifampicin or rifampin (USAN) is a bacteriostatic antibiotic drug of the rifamycin group. It is a semisynthetic compound derived from Streptomyces mediterranei. Rifampicin may be abbreviated RIF, RMP, RD or R.

    Indications

It is typically used to treat Mycobacterium infections, including tuberculosis and leprosy; and also has a role in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in combination with fusidic acid. It is used in prophylactic therapy against Neisseria meningitidis (meningococcal) infection.

It is also used to treat Listeria species, Neisseria gonorrhoeae, Haemophilus influenzae and Legionella pneumophila For these non-standard indications, sensitivity testing should be done (if possible) before starting rifampicin therapy. Rifampicin resistance develops quickly during treatment and rifampicin monotherapy should not be used to treat these infections it should be used in combination with other antibiotics.

Enterobacteriaceae, Acinetobacter and Pseudomonas species are intrinsically resistant to rifampicin.

Mechanism of action

Rifampicin inhibits DNA-dependent RNA polymerase in bacterial cells by binding its beta subunit, thus preventing transcription of messenger RNA (mRNA) and subsequent translation to proteins.