Topiramate

Brief Description
CAS No.: 97240-79-4 Other Names: Topamax MF: C12H21NO8S
EINECS No.: 10 Place of Origin: Shaanxi China (Mainland) Type: Antipyretic Analgesics and NSAIDs
Grade Standard: Medicine Grade Brand Name: sciphar Model Number: 01
Purity: 98 product name: Topiramate Molecular weight: 339.36
Purity: 98% By HPLC  
Delivery Terms & Packaging
Packaging Detail:25kgs
Delivery Detail:3days
Specifications
Topiramate

Topiramate is an anticonvulsant indicated in the treatment of epilepsy and migraine

Topiramate is an anticonvulsant indicated in the treatment of epilepsy and migraine. Topiramate enhances GABA-activated chloride channels. In addition, topiramate inhibits excitatory neurotransmission, through actions on kainate and AMPA receptors. There is evidence that topiramate has a specific effect on GluR5 kainate receptors. It is also an inhibitor of carbonic anhydrase, particular subtypes II and IV, but this action is weak and unlikely to be related to its anticonvulsant actions, but may account for the bad taste and the development of renal stones seen during treatment. Its possible effect as a mood stabilizer seems to occur before anticonvulsant qualities at lower dosages. Topiramate inhibits maximal electroshock and pentylenetetrazol-induced seizures as well as partial and secundarily generalized tonic-clonic seizures in the kindling model, findings predective of a broad spectrum of antiseizure activities clinically.