chloroamphenicol; CAS RN.:56-75-7

Brief Description
CAS No.: 56-75-7 Other Names: 2,2-dichloro-n-[2-hydroxy-1-(hydro... MF: C11H12Cl2N2O5
EINECS No.: 200-287-4 Place of Origin: Zhejiang China (Mainland) Type: Antibiotic and Antimicrobial Agents
Grade Standard: Medicine Grade Usage: Animal Pharmaceuticals Brand Name: DERY
Model Number: DR-HM-001A Purity: 99% 
Delivery Terms & Packaging
Packaging Detail:25kg/drum 25cm*25cm*36cm or customized packing when larger or smaller than 25kg
Delivery Detail:In 15-20 days upon the receipt of the payment
Specifications
chloroamphenicol; CAS RN.:56-75-7

1. CAS RN.:56-75-7;
2. Spec.:USP33/EP6th/BP2010
3. the dominant products of our company;
4. high quality & competitive price;

Product Name:chloroamphenicol

Synonyms:

chloramphenicol; 2,2-dichloro-n-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide; d-(-)-threo-2,2-dichloro-n-[beta-hydroxy-alpha-(hydroxy-methyl)-p-nitrophenethyl]acetamide; chloromycetin; 2,2-dichloro-N-[(1R,2S)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide; 2,2-dichloro-N-[(1S,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide; 2,2-dichloro-N-[(1R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
CAS RN.: 56-75-7
EINECS:200-287-4
Molecular Weight:323.1294
Molecular Formula:C11H12Cl2N2O5

Standards: CP2010/USP33/EP6th/BP2010/IP2007

Chraracters 

A white, greyish-white or yellowish-white, fine, crystalline powder or fine crystals,  needles or elongated plates, slightly soluble in water, freely soluble in alcohol and in  propylene glycol. A solution in ethanol is dextrorotatory and a solution in ethyl acetate is laevorotatory.

general info:Chloramphenicol  is a bacteriocidal antimicrobial. It is considered a prototypical broad-spectrum antibiotic, alongside the tetracyclines.

General introduction: 
Chloramphenicol is effective against a wide variety of Gram-positive and Gram-negative bacteria, including most anaerobic organisms. Due to resistance and safety concerns, it is no longer a first-line agent for any indication in developed nations, although it is sometimes used topically for eye infections; nevertheless, the global problem of advancing bacterial resistance to newer drugs has led to renewed interest in its use.In low-income countries, chloramphenicol is still widely used because it is exceedingly inexpensive and readily available.

Indications:
The most serious adverse effect associated with chloramphenicol treatment is bone marrow toxicity, which may occur in two distinct forms: bone marrow suppression, which is a direct toxic effect of the drug and is usually reversible, and aplastic anemia, which is idiosyncratic (rare, unpredictable, and unrelated to dose) and generally fatal.

ItemStandardResult
CharactersFine, white to grayish-white or yellowish white, needle-like crystals or elongated plates.Qualified
IdentificationIRQualified
HPLC
Melting range149°C~153°C149.0~151.5°C
Specific rotation +18.5 ~ +20.0+19.60°
CrystallinityMeets the requirementsQualified
pH4.5-7.54.94
Chromatographic purityIndividual impurity≤0.5%,Total impurities≤2%Qualified
Residual solventsMethanol≤0.3%0.00%
Methyl dichloroacetate≤0.5%0.00%
Benzoic aldehyde≤0.5%0.00%
Assay98.5-102.099.79%

Storage:

kept in a light-proof,well-colsed,dry and cool place.