high quality Gemcitabine HCL//122111-03-9 99.9% min

Brief Description
Place of Origin: Anhui China (Mainland) Brand Name: TNJ Model Number: TNJ
Delivery Terms & Packaging
Packaging Detail:25kg/fiber can
Delivery Detail:Within one week after payment done.
high quality Gemcitabine HCL//122111-03-9 99.9% min

1.Product name:Gemcitabine HCL
3.Molecular formula:C9H12ClF2N3O4
4.Purity:99% min

Product name: Gemcitabine HCl


Molecular formula:C9H12ClF2N3O4

Purity: 99% min

Appearance:white powder

Usage: Antineoplastic

Packing: 25kg per drum

Delivery: Within one week after payment done.


Pharmacology:Chemically gemcitabine is a nucleoside analog in which the hydrogen atoms on the 2' carbons of deoxycytidine are replaced by fluorine atoms.

As with fluorouracil and other analogues of pyrimidines, the triphosphate analogue of gemcitabine replaces one of the building blocks of nucleic acids, in this case cytidine, during DNA replication. The process arrests tumor growth, as only one additional nucleoside can be attached to the "faulty" nucleoside, resulting in apoptosis.

Another target of gemcitabine is the enzyme ribonucleotide reductase (RNR). The diphosphate analogue binds to RNR active site and inactivates the enzyme irreversibly. Once RNR is inhibited, the cell cannot produce the deoxyribonucleotides required for DNA replication and repair, and cell apoptosis is induced.

Indications:Gemcitabine is used in various carcinomas: non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. It is being investigated for use in esophageal cancer, and is used experimentally in lymphomas and various other tumor types. Gemcitabine represents an advance in pancreatic cancer care. It is also not as debilitating as some other forms of chemotherapy.

A study reported in the Journal of the American Medical Association suggested that gemcitabine shows benefit in patients with pancreatic cancer who were felt to have successful tumor resections.